Transcriptome patterns and blood physiology associated with homing success of sockeye salmon during their final stage of marine migration
Bibliographic record
Abstract
To better understand the mechanisms that lead to marine mortality of homing adult sockeye salmon (Oncorhynchus nerka), gill and blood biopsies were used in combination with biotelemetry to demonstrate how survival to freshwater entry is related to gene expression and physiological indices of stress. Microarray analysis of gene expression indicated multiple biological processes, including immune and stress responses, protein biosynthesis, and metabolism. Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) analysis indicated fish with upregulation of genes related to stress and infection had higher marine survival compared with fish without this genomic signature. We proposed that higher marine survival of potentially stressed and immune compromised fish can be explained by stressed and infected fish being highly motivated to enter fresh water, leading to enhanced marine survival. However, once in a river, stressed and immune compromised fish could suffer higher mortality because of premature river entry. Overall, this study supports the idea that infection and stress are important biological processes influencing behaviour and fate of sockeye salmon during homing migrations.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".