Abstract 18757: Adenylate Cyclase Type 9 (Adcy9) Regulates Vasomotor Tone in Mice
Bibliographic record
Abstract
Single nucleotide polymorphisms located in the adenylate cyclase type 9 (ADCY9) gene determine cardiovascular outcomes of patients treated with dalcetrapib, a cholesteryl ester transfer protein inhibitor (Tardif et al, Circ Cardiovasc Genetics 2015). The roles of the different subtypes of adenylate cyclases responsible for vasodilatation (VD) are ill-defined. We aimed at evaluating the role of Adcy9 expression in the control of vascular tone by using isolated vessels from Adcy9-inactivated (Adcy9Gt) and wild-type (WT) mice. Vasomotor tone was studied by recording the isometric tension developed by aorta rings and the diameter of pressurized isolated femoral arteries from mice aged 8 to 13 weeks. We studied VD in response to adenylate cyclase activators, isoproterenol (Iso), a β-adrenergic receptor (β-AR) agonist and iloprost, a prostaglandin I2 receptor agonist, as well as endothelial-dependent vasodilatation (EDV) in response to acetylcholine (Ach). EDV and β-AR-induced VD in the aorta were similar in WT and Adcy9Gt mice. In femoral arteries, Adcy9 inactivation decreased Iso-induced VD (Emax, WT: 48.3+/-4.7%, n=7; Adcy9Gt: 24.1+/-4.7%, n=11; P
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.003 |
| Insufficient payload (model declined to judge) | 0.012 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".