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Record W2781976437 · doi:10.1016/j.ajhg.2017.12.005

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

2018· review· en· W2781976437 on OpenAlexaff
Carolina Medina‐Gómez, John P. Kemp, Katerina Trajanoska, Jian’an Luan, Alessandra Chesi, Tarunveer S. Ahluwalia, Dennis O. Mook‐Kanamori, Annelies C. Ham, Fernando Pires Hartwig, Daniel S. Evans, Raimo Joro, Ivana Nedeljković, Hou‐Feng Zheng, Kun Zhu, Mustafa Atalay, Ching‐Ti Liu, Maria Nethander, Linda Broer, Gudmar Porleifsson, Benjamin H. Mullin, Samuel K. Handelman, Mike A. Nalls, Leon Eyrich Jessen, Denise H. M. Heppe, J. Brent Richards, Carol A. Wang, Bo Chawes, Katharina E. Schraut, Najaf Amin, David Karasik, Nathalie van der Velde, M. Arfan Ikram, Babette S. Zemel, Yanhua Zhou, Christian J. Carlsson, Fiona E. McGuigan, Cindy G. Boer, Klaus Bønnelykke, Stuart H. Ralston, John A. Robbins, John P. Walsh, M. Carola Zillikens, Claudia Langenberg, Ruifang Li‐Gao, Frances M. K. Williams, Tamara B. Harris, Kristina Åkesson, Rebecca D. Jackson, Gunnar Sigurðsson, Martin den Heijer, Bram C. J. van der Eerden, Jeroen van de Peppel, Timothy D. Spector, Craig E. Pennell, Bernardo Lessa Horta, Janine F. Felix, Jing Hua Zhao, Scott G. Wilson, Renée de Mutsert, Hans Bisgaard, Unnur Styrkársdóttir, Vincent W. V. Jaddoe, Eric Orwoll, Timo A. Lakka, Robert A. Scott, Struan F.A. Grant, Mattias Lorentzon, Cornelia M. van Duijn, James F. Wilson, Bruce M. Psaty, Douglas P. Kiel, Claes Ohlsson, Evangelia Ntzani, André J. van Wijnen, Vincenzo Forgetta, Mohsen Ghanbari, John G. Logan, Graham R. Williams, J. H. Duncan Bassett, Peter I. Croucher, Εvangelos Εvangelou, André G. Uitterlinden, Cheryl L. Ackert‐Bicknell, Jonathan H. Tobias, David M. Evans, Fernando Rivadeneira

Bibliographic record

VenueThe American Journal of Human Genetics · 2018
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsCentre for Global Health ResearchMcGill UniversityJewish General Hospital
FundersNational Heart, Lung, and Blood InstituteNational Institute on AgingNational Cancer InstituteLundbeckfondenNovo Nordisk FondenMedical Research CouncilSteno Diabetes Center CopenhagenNational Institute for Health and Care ResearchNational Center for Advancing Translational SciencesNational Institute of Arthritis and Musculoskeletal and Skin DiseasesMichael J. Fox Foundation for Parkinson's Research
KeywordsMeta-analysisLife course approachAssociation (psychology)Genome-wide association studyMedicinePsychologyBiologyGeneticsInternal medicineDevelopmental psychologyGeneGenotypeSingle-nucleotide polymorphism

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: Meta-analysis
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.240
Threshold uncertainty score0.974

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0040.002
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.057
GPT teacher head0.381
Teacher spread0.324 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designMeta-analysis
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations361
Published2018
Admission routes1
Has abstractno

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