The<b><i> IL20</i></b> Genetic Polymorphism Is Associated with Altered Clinical Outcome in Septic Shock
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Bibliographic record
Abstract
<b><i>Background:</i></b> The <i>IL10</i> family of genes includes crucial immune regulators.<b> </b>We tested the hypothesis that single nucleotide polymorphisms (SNPs) in <i>IL10</i>, <i>IL19</i>, <i>IL20</i>, and <i>IL24</i> of the <i>IL10</i> family gene cluster alter the clinical outcome of septic shock. <b><i>Methods:</i></b> Patients with septic shock (<i>n</i> = 1,193) were genotyped for 13 tag SNPs of <i>IL10</i>, <i>IL19</i>, <i>IL20</i>, and <i>IL24</i>. <i>IL20</i> gene expression was measured in genotyped lymphoblastoid cells in vitro. Cardiac surgical ICU patients (<i>n</i> = 981) were genotyped for <i>IL20</i> rs2981573 A/G. The primary outcome variable was 28-day mortality. <b><i>Results:</i></b> Patients with the G allele of<i> IL20</i> rs2981573 had a significantly increased hazard of death over the 28-day period compared to patients with the A allele in the septic shock cohort (adjusted hazard ratio 1.27; 95% confidence interval 1.10-1.47; <i>p</i> = 8.0 × 10<sup>-4</sup>). Patients with the GG genotype had more organ dysfunction (<i>p</i> < 0.05). The GG genotype was associated with increased <i>IL20</i> gene expression in stimulated lymphoblastoid cells in vitro (<i>p</i> < 0.05). The cardiac surgical ICU patients with the GG genotype had an increased length of ICU stay (<i>p</i> = 0.032). <b><i>Conclusions:</i></b> The GG genotype of <i>IL20</i> rs2981573 SNP was associated with increased <i>IL20</i> gene expression and increased adverse outcomes in patients with septic shock and following cardiac surgery.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.006 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it