A deep learning pipeline to classify different stages of Alzheimer's disease from fMRI data
Bibliographic record
Abstract
Alzheimer's disease (AD) is an irreversible, progressive neurological disorder that causes memory and thinking skill loss. Many different methods and algorithms have been applied to extract patterns from neuroimaging data in order to distinguish different stages of Alzheimer's disease (AD). However, the similarity of the brain patterns in older adults and in different stages makes the classification of different stages a challenge for researchers. In this paper, convolutional neuronal network architecture AlexNet was applied to fMRI datasets to classify different stages of the disease. We classified five different stages of Alzheimer's using a deep learning algorithm. The method successfully classified normal healthy control (NC), significant memory concern (SMC), early mild cognitive impair (EMCI), late cognitive mild impair (LMCI), and Alzheimer's disease (AD). The model was implemented using GPU high performance computing. Before applying any classification, the fMRI data were strictly preprocessed. Then, low to high level features were extracted and learned using the AlexNet model. Our experiments show significant improvement in classification. The average accuracy of the model was 97.63%. We then tested our model on test datasets to evaluate the accuracy of the model per class, obtaining an accuracy of 94.97% for AD, 95.64% for EMCI, 95.89% for LMCI, 98.34% for NC, and 94.55% for SMC.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.010 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".