Abstract 14239: Wall Stress-Mediated Rgs5 Expression in Vascular Smooth Muscle Cells Controls Arterial Remodeling During Hypertension
Bibliographic record
Abstract
The onset of hypertension is characterized by an increase in arterial wall stress which results in a compensatory remodeling of the vascular wall which ultimately leads to arterial stiffening. While G-protein signaling has been reported to control contraction and differentiation of vascular smooth muscle cells (VSMCs) in this context, the role of the regulators of G-protein signaling (RGS) has not been elucidated in detail. While earlier reports demonstrate that RGS5 regulates biomechanically induced arterial growth (arteriogenesis), we aimed at investigating the relevance of RGS5 for hypertension-induced VSMC responses. In vitro, exposing VSMCs to biomechanical stretch increased RGS5 protein abundance (3.2-fold, p<0.05, n=3). Likewise, RGS5 mRNA expression was augmented in isolated arteries in response to increased wall stress (1.7-fold, p<0.05, n=13). As evidenced by a whole genome microarray, overexpression of RGS5 under these conditions shifted the transcriptome towards expression of RhoA pathway-asso...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".