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Record W2786658716 · doi:10.1373/clinchem.2017.281378

Microfluidics: The Future of Testing?

2018· article· en· W2786658716 on OpenAlexaff
Sarah Delaney, Brenda B. Suh-Lailam

Bibliographic record

VenueClinical Chemistry · 2018
Typearticle
Languageen
FieldEngineering
TopicMicrofluidic and Capillary Electrophoresis Applications
Canadian institutionsHospital for Sick ChildrenUniversity of Toronto
Fundersnot available
KeywordsPhotomaskMicrofluidicsPhotoresistPhotolithographyPolydimethylsiloxaneNanotechnologyMaterials scienceLithographySubstrate (aquarium)MiniaturizationReticleResistOptoelectronicsWafer

Abstract

fetched live from OpenAlex

The past few decades have seen a promising trend in point-of-care diagnostics, with microfluidic technologies at the cornerstone of this emerging field. Microfluidic devices are platforms the size of a microscope slide, or smaller, that are comprised of various circuits connected by miniature tubing systems. These technologies can be coupled to many common analytical detection techniques and promise rapid simultaneous analyses and automatic reporting, while utilizing minute volumes of samples and reagents (1). Microfluidic chips are typically made out of a transparent polymer, polydimethylsiloxane, through a process called photolithography. A silicon plate is covered with a printed “photomask.” With exposure to UV light, the pattern on the photomask is transferred to a light-sensitive chemical “photoresist” on the silicon substrate. The photoresist resists subsequent chemical treatments, allowing an inverse image of the photomask pattern to be engraved into the silicon. This engraved image serves as a mold for the chip. Polydimethylsiloxane is poured over the mold and hardened to create the final chip. More recently, 3D printing has been employed to create microfluidic chips, which has greatly simplified the process of creating 3D chips. A 3D printer builds the shape of the circuits with plastic and is then submerged in polydimethylsiloxane to produce the chip.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.022
metaresearch head score (Gemma)0.018
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.022
Threshold uncertainty score0.118

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0220.018
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0030.001
Bibliometrics0.0030.002
Science and technology studies0.0010.015
Scholarly communication0.0090.022
Open science0.0040.004
Research integrity0.0090.008
Insufficient payload (model declined to judge)0.0210.007

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.017
GPT teacher head0.268
Teacher spread0.251 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations6
Published2018
Admission routes1
Has abstractyes

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