A297 FREQUENT ADVERSE CHILDHOOD EVENTS IN PATIENTS WITH IBS AND ORGANIC GASTROINTESTINAL DISORDERS
Bibliographic record
Abstract
Stressful events in childhood have been associated with the development of functional bowel disorders in adulthood, especially irritable bowel syndrome. However, it not known whether early life adverse events affect patients with common organic disorders, including celiac disease and IBD. To evaluate the association between early life adverse events and gastrointestinal and extra-intestinal symptoms in patients with functional and organic gastrointestinal (GI) disorders compared with healthy controls. We included adult patients with a diagnosis of IBS (Rome III criteria), organic GI disorders (celiac disease and IBD) and healthy volunteers (HV). Patients and controls were interviewed by a psychologist and early life adverse events assessed during the semi-structured interview using a modified version of the Adverse Childhood Experience (ACE) questionnaire. We quantified number of early life events and the presence of gastrointestinal and extraintestinal symptoms in each group. Data are presented as median (IQR) and n (%). We enrolled thirty subjects (16 IBS patients, 8 with organic GI disorders and 6 healthy controls). Patients with IBS had significantly increased number of early life events compared with healthy controls (12 (9–15) vs 3 (1–6); p=0.003). The number of overall early life events in IBS patients was comparable to those with a diagnosis of organic GI disorders. Compared to HV, both patients with IBS and organic GI disorders had significantly increased number of family members with alcohol or drugs abuse during childhood (IBS vs HV p=0.0028; chronic GI disorders vs HV p=0.03) and neglected parents (IBS vs HV p=0.01; chronic GI disorders vs HV p=0.004). Parental conflicts or divorce (p=0.004) and motor vehicle accidents (p=0.049) were more common in IBS patients compared to HV. The number of overall early life adverse events were strongly correlated with number of gastrointestinal (r= 0.91; p=0.01) and extra-intestinal (r=0.87; p=0.02) symptoms, but not with symptoms severity. Our preliminary results show that adverse early life events are frequent in patients with functional and organic gastrointestinal conditions, which may contribute to symptoms in adulthood. The association between number of childhood adverse events and the presence of gastrointestinal and extraintestinal symptoms highlight the need for better psychosocial assessment in gastroenterology clinical practice to improve the management of these patients. None
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".