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Record W2789587972 · doi:10.1073/pnas.1720554115

A comprehensive genomic history of extinct and living elephants

2018· article· en· W2789587972 on OpenAlexafffund
Eleftheria Palkopoulou, Mark Lipson, Swapan Mallick, Svend Vendelbo Nielsen, Nadin Rohland, Sina Baleka, Emil Karpinski, Atma M. Ivancevic, Thu-Hien To, R. Daniel Kortschak, Joy M Raison, Zhipeng Qu, Tat-Jun Chin, Kurt W. Alt, Stefan Claesson, Love Dalén, R. D. E. MacPhee, Harald Meller, Alfred L. Roca, Oliver A. Ryder, David I. Heiman, Sarah Young, Matthew Breen, Christina L. Williams, Bronwen Aken, Magali Ruffier, Elinor K. Karlsson, Jeremy Johnson, Federica Di Palma, Jessica Alföldi, David L. Adelson, Thomas Mailund, Kasper Munch, Kerstin Lindblad‐Toh, Michael Hofreiter, Hendrik N. Poinar, David Reich

Bibliographic record

VenueProceedings of the National Academy of Sciences · 2018
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic diversity and population structure
Canadian institutionsMcMaster University
FundersNational Institute of General Medical SciencesBiotechnology and Biological Sciences Research CouncilNatural Sciences and Engineering Research Council of CanadaUniversity of Illinois at Urbana-ChampaignEuropean Molecular Biology LaboratoryNational Human Genome Research InstituteWellcome TrustNational Science FoundationUniversity of WashingtonU.S. Fish and Wildlife ServiceBroad InstituteMcMaster UniversityUniversity of WyomingNational Institutes of HealthCanada Research ChairsHoward Hughes Medical Institute
KeywordsGeographyAncient DNABiologyEvolutionary biologyArchaeologyHistoryGenealogySociologyDemography

Abstract

fetched live from OpenAlex

Elephantids are the world's most iconic megafaunal family, yet there is no comprehensive genomic assessment of their relationships. We report a total of 14 genomes, including 2 from the American mastodon, which is an extinct elephantid relative, and 12 spanning all three extant and three extinct elephantid species including an ∼120,000-y-old straight-tusked elephant, a Columbian mammoth, and woolly mammoths. Earlier genetic studies modeled elephantid evolution via simple bifurcating trees, but here we show that interspecies hybridization has been a recurrent feature of elephantid evolution. We found that the genetic makeup of the straight-tusked elephant, previously placed as a sister group to African forest elephants based on lower coverage data, in fact comprises three major components. Most of the straight-tusked elephant's ancestry derives from a lineage related to the ancestor of African elephants while its remaining ancestry consists of a large contribution from a lineage related to forest elephants and another related to mammoths. Columbian and woolly mammoths also showed evidence of interbreeding, likely following a latitudinal cline across North America. While hybridization events have shaped elephantid history in profound ways, isolation also appears to have played an important role. Our data reveal nearly complete isolation between the ancestors of the African forest and savanna elephants for ∼500,000 y, providing compelling justification for the conservation of forest and savanna elephants as separate species.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.635
Threshold uncertainty score0.285

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.039
GPT teacher head0.274
Teacher spread0.235 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations213
Published2018
Admission routes2
Has abstractyes

Explore more

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