Atypical behavioural, metabolic and thermoregulatory responses to hypoxia in the naked mole rat (<i>Heterocephalus glaber</i>)
Bibliographic record
Abstract
Abstract Hypoxia compromises aerobic energy production at the cellular level, but hypoxic environments are commonly encountered by mammals. In response, mammals typically exhibit compensatory physiological and behavioural adaptations that help to restore energetic homeostasis by reducing physical activity and body temperature ( T b ) to lower metabolic demand. Naked mole rats ( NMR s; Heterocephalus glaber ) are among the most hypoxia‐tolerant mammals identified but their behavioural and thermal responses to acute hypoxia are poorly characterized. Using behavioural tracking software, we examined the effects of acute hypoxia (1 h at 7% O 2 ) on physical activity and T b in animals held at their natural burrow temperature (30°C), or at temperatures above (38°C) or below (20°C). In separate experiments, we used respirometry to measure metabolic rate under the same conditions. Physical activity decreased ~26–60% and T b decreased by ~ 1.9–3.7°C during hypoxia in all temperatures. Normoxic metabolic rate was highest at 20°C, but was suppressed to similar rates in hypoxia across all temperatures. When animals were given the opportunity to escape their burrow temperature to either warmer or colder chambers during the hypoxic episode, NMR s surprisingly avoided the cold chamber, suggesting they are unable to take advantage of anapyrexia. Conversely, NMR s were able to use behavioural thermoregulation to maintain T b in hypoxia when given the choice of temperatures within and above their burrow temperature. Taken together, these findings indicate that NMR s respond to acute hypoxia with reversible decreases in physical activity, T b and metabolic rate across a range of ambient temperatures to reduce oxygen requirements.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".