Lateral cerebellum is preferentially sensitive to high sonic hedgehog signaling and medulloblastoma formation
Bibliographic record
Abstract
Significance Cerebellar tumor medulloblastoma (MB) is no longer considered a single disease as it has been separated into four subgroups with further subdivisions based on genomic and clinical data. Mechanistic understandings of the stratification within subgroups should allow for better-targeted treatments. We redefined the main cell of origin by showing that granule cell precursors (GCPs) are heterogeneous with molecularly distinct populations based on their location. As a consequence, GCPs respond differentially to two driver mutations, and a subset of GCPs is more susceptible to Sonic hedgehog (SHH) pathway elevation and forms tumors more readily. These results provide insights into the preferential location of human SHH-MBs in the lateral cerebellum and the cellular and genetic factors influencing SHH-MB progression.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".