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Record W2790035416 · doi:10.1183/13993003.02330-2017

Characteristics, treatment and outcomes of nontuberculous mycobacterial pulmonary disease after allogeneic haematopoietic stem cell transplant

2018· letter· en· W2790035416 on OpenAlexafffund
Takashi Hirama, Sarah K. Brode, Jenifer Beswick, Arjun Law, Wilson Lam, Fotios V. Michelis, Santhosh Thyagu, Auro Viswabandya, Jeffrey H. Lipton, Hans A. Messner, Dennis Dong Hwan Kim, Theodore K. Marras

Bibliographic record

VenueEuropean Respiratory Journal · 2018
Typeletter
Languageen
FieldMedicine
TopicMycobacterium research and diagnosis
Canadian institutionsWest Park Healthcare CentrePrincess Margaret Cancer CentreToronto Western HospitalUniversity of Toronto
FundersUniversity of Toronto
KeywordsNontuberculous mycobacteriaMedicineTransplantationIncidence (geometry)Stem cellHematopoietic stem cell transplantationHaematopoiesisPopulationDiseaseImmunologyInternal medicineTuberculosisMycobacteriumPathologyBiologyEnvironmental health

Abstract

fetched live from OpenAlex

Allogeneic haematopoietic stem cell transplant (alloHCT) recipients are at risk for a variety of opportunistic infections. While typical bacterial infections occur most frequently, nontuberculous mycobacteria (NTM) are becoming increasingly recognised as pathogens after alloHCT [1]. The prevalence of NTM pulmonary disease (NTM-PD) is increasing worldwide, with a rise in Ontario's period prevalence from 29.3 per 100 000 in 1998–2002 to 41.3 per 100 000 in 2006–2010 [2]. Likewise, the incidence of NTM-PD post alloHCT increased from 0.11–0.23% [3, 4] in early studies to 2.7–3.15% in recent investigations [5, 6]. Despite the incidence of NTM-PD after alloHCT being far higher than in the general population [6], there are few reports addressing management and treatment outcomes of NTM-PD after alloHCT. We reviewed the experience with NTM-PD among alloHCT recipients at our institution to better characterise clinical features and treatment outcomes. Nontuberculous mycobacterial pulmonary disease in allogeneic haematopoietic stem cell transplant recipients

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.010
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.004
Threshold uncertainty score0.010

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.010
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0010.000
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0040.004
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.254
Teacher spread0.231 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations17
Published2018
Admission routes2
Has abstractyes

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