A132 THREE QUARTERS OF INFLAMMATORY BOWEL DISEASE PATIENTS ON MAINTENANCE INFLIXIMAB THERAPY IN CLINICAL REMISSION SHOW EVIDENCE OF MUCOSAL INFLAMMATION WITH ELEVATED FECAL CALPROTECTIN
Bibliographic record
Abstract
Fecal calprotectin (FCP) has been demonstrated to be a noninvasive marker of mucosal inflammation and when elevated, correlates with endoscopic mucosal disease activity in patients with Ulcerative Colitis (UC) and Crohn’s Disease (CD). Endoscopic mucosal healing and normalization of FCP represents desired therapeutic results in these patients as it has shown to improve patient outcomes by reducing hospitalization and surgery. To determine the proportion of patients with UC and CD in clinical remission on maintenance infliximab (IFX) therapy who had elevated FCP test results. Sequential UC and CD patients over 18 years of age attending an IFX infusion clinic at the University of Alberta completed a Partial Mayo Score (pMS) or Harvey Bradshaw Index (HBI), as a determinant of clinical remission or disease activity, and were given a FCP test kit to voluntarily complete and return. FCP was determined using ELISA methodology. FCP test kits were given to 243 patients and 98 (40.3%) returned the kit for analysis (22 UC, 76 CD). Patients were separated by 4 categories: FCP ≥ 250 mcg/g, FCP ≥ 100 mcg/g, FCP < 250 mcg/g and FCP < 100 mcg/g. Twenty-three patients had FCP levels ≥ 250 (8 UC, 15 CD) of which, 78.3% were in remission, as indicated by pMS or HBI. Forty-one patients had FCP levels ≥ 100 (12 UC, 29 CD) of which, 73.2% were in clinical remission. Seventy-four patients had FCP levels < 250 (14 UC, 60 CD), of which, 79.7% were in clinical remission. Fifty-six patients had FCP levels < 100 (10 UC, 46 CD) of which, 83.9% were in clinical remission. Table 1 summarizes patient results for UC and CD. Over 75% of patients on maintenance IFX therapy identified as being in clinical remission, as per disease activity scoring, yet show evidence of mucosal inflammation with elevated FCP tests. This suggests that to achieve a therapeutic outcome of mucosal healing with inflammatory bowel disease therapy, objective monitoring should be routinely conducted in all patients. FCP concentrations for 98 IBD patients in clinical remission at the University of Alberta None
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".