A273 HISTOLOGICAL FINDINGS IN GASTRIC BIOPSIES AT DIAGNOSIS IN AN ADULT CELIAC DISEASE POPULATION
Bibliographic record
Abstract
Chronic gastritis (CG) and lymphocytic gastritis (LG) have been described in pediatric populations with celiac disease (CeD). A US national review of gastric and duodenal biopsies showed an association between duodenal histology compatible with CeD and the presence of CG or LG. However, this transversal study did not include clinical or serological data. To evaluate, in an adult CeD cohort, the gastric histological findings at diagnosis of CeD. Longitudinal chart review study at Centre Hospitalier de l’Université de Montréal from August 2003 to June 2016. Were included every new cases of CeD (presence of tissue transglutaminase antibodies (tTG) and duodenal biopsies corresponding to Marsh 1 to 3c classification, without any notion of previous gluten-free diet). Medical record, endoscopic and pathology reports were reviewed. Mann-Whitney U test was used to compare continuous data and Fisher’s exact test to compare categorical data. 186 cases of CeD were diagnosed (mean age(SD) 47.3 ± 15.9 years; 64% female). Concomitant gastric biopsies were done in 43% of them (n=80). Gastroscopy findings were abnormal in 33.8% (n=27), the main finding being mucosal erythema (n=18). Gastric histology was abnormal in 63,75% (n=51). Findings included inactive CG(n=27), active CG without helicobacter pylori (Hp) (n=7), Hp infection (n=5), reactional gastropathy (n=4), gastric polyps (n=2), LG (n=3), parietal cells pseudohypertrophy (n=2) and intestinal metaplasia(n=1). No difference was found between the level of increase of tTG in the subgroup with abnormal gastric histologic findings (his+) and the subgroup with normal findings (his-). The two groups were also similar for the proportion of patients with moderate to severe duodenal villous atrophy. Among patients with his+, 58,8% had a normal endoscopic appearance of the stomach, compared to 79,3% in the group with his-(p=0,09). No difference was found between the proportion of patients with GI symptomatology or anemia in his+ and his- groups. Gastric histologic findings at diagnosis in an adult population with celiac disease are variable and do not seem associated with severity of celiac disease. None
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".