A125 PERICARDITIS AND 5-ASA EXPOSURE IN INFLAMMATORY BOWEL DISEASE: TWO PAEDIATRIC CASE REPORTS
Bibliographic record
Abstract
5-aminosalicylic acid-containing products are often used as first-line treatment in inflammatory bowel disease (IBD). Pericarditis has been reported as a rare extraintestinal inflammatory manifestation of IBD and as a side effect of 5-ASA, when it usually occurs soon after starting the drug. Clinical presentations range from asymptomatic pericardial effusions to potentially life-threatening cardiac tamponade. Recognition as a possible side effect of 5-ASA necessitating cessation is important. We report two paediatric cases presenting with chest pain and fever, elevated cardiac enzymes and electro/echocardiographic evidence of pericarditis. Infectious causes of pericarditis were excluded. One of the patients received 5-ASA for one month prior to developing pericarditis, whereas the other received 5-ASA for eighteen months. In the second case, the patient soon had a flare of colitis symptoms, and so treatment was restarted five days later. Pericarditis symptoms recurred within six days and 5-ASA was immediately stopped with prompt resolution of symptoms. Both patients then went on to receive maintenance therapy with infliximab, with good effect. Pericarditis in inflammatory bowel disease is a rare occurrence with a multifactorial origin. The pathophysiology of 5-ASA induced pericarditis is not completely understood. Treatment includes prompt cessation of the drug, supportive care, and close monitoring for complete resolution of cardiovascular symptoms. Given the common use of 5-ASA in the treatment of IBD, physicians should keep this potentially severe complication in mind. CAG
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.006 |
| Meta-epidemiology (narrow) | 0.003 | 0.003 |
| Meta-epidemiology (broad) | 0.002 | 0.002 |
| Bibliometrics | 0.004 | 0.002 |
| Science and technology studies | 0.002 | 0.003 |
| Scholarly communication | 0.002 | 0.003 |
| Open science | 0.002 | 0.003 |
| Research integrity | 0.010 | 0.005 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".