A Randomized Placebo Controlled Clinical Trial to Determine the Impact of Digestion Resistant Starch MSPrebiotic® on Glucose, Insulin, and Insulin Resistance in Elderly and Mid-Age Adults
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Introduction: Type 2 Diabetes (T2D) has reached epidemic proportions in North America. Recent evidence suggests that prebiotics can modulate the gut microbiome, which then plays an important role in regulating lipid metabolism, blood glucose, and insulin sensitivity. As such, prebiotics are appealing potential therapeutic strategies for pre-diabetes and T2D. The key objectives of this study were to determine the tolerability as well as the glucose and insulin modulating ability of MSPrebiotic® digestion resistant starch in healthy middle aged and elderly adults. Materials and Methods: This was a prospective, blinded, placebo controlled study. Pre-diabetes and diabetes were among the exclusion factors. Elderly (>70 years) and mid-age (30 to 50 years) Canadian adults were recruited and, after 2 weeks of consuming placebo, they were randomized to consume 30 grams of either MSPrebiotic® or placebo per day for 12 weeks. In total, 42 elderly and 42 mid-age participants completed the study. Blood samples were collected over the 14 week study and analyzed for glucose, lipid profile, and CRP, lipid particles, TNF-α, IL-10, insulin and insulin resistance. Results: At baseline, the elderly population had a significantly higher percentage (p <0.01) with elevated glucose and significantly higher TNF-α (p < 0.01) compared to mid-age adults. MSPrebiotic® digestion resistant starch was well tolerated in both mid-age and elderly adults. There was a significant difference over time in blood glucose (p = 0.0301) and insulin levels (p = 0.009), as well as insulin resistance (HOMA-IR; p = 0.009) in elderly adults who consumed MSPrebiotic® compared to placebo. No significant changes were found in mid-age adults. Conclusions: Our results suggest that dietary supplementation with prebiotics such as MSPrebiotic® may be part of an effective strategy to reduce insulin resistance, a major risk factor for developing T2D, in the elderly.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it