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Are universal upper reference limits for alanine aminotransferase (ALT) appropriate for assessing pediatric liver injury?

2018· article· en· 9 citations· W2791532955 on OpenAlex· 10.1016/j.clinbiochem.2018.01.010

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

The three-model screen

all 1,000 screened works →

All three models called this out of scope.

stratum: aff_core · design weight: 5595.24 (the sample is stratified; any rate computed without the weight is wrong)
Claude Opus 4.8OUT
genre: empirical
about Canada: no
confidence: high

No abstract; question about the appropriateness of clinical laboratory reference limits for ALT in children; clinical chemistry.

GPT-5.6 (high)OUT
genre: empirical
about Canada: no
confidence: low

The title indicates a clinical study of pediatric liver-injury reference limits.

Grok 4.5OUT
genre: empirical
about Canada: no
confidence: medium

Clinical question on pediatric ALT reference limits for liver injury; laboratory medicine, not methods research (no abstract).

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Clinical Biochemistry
Topic
Liver Disease Diagnosis and Treatment
Field
Medicine
Canadian institutions
Université de MontréalCentre Hospitalier Universitaire Sainte-JustineHospital for Sick ChildrenUniversity of Toronto
Funders
Keywords
Alanine aminotransferaseMedicineLiver injuryInternal medicine
Has abstract in OpenAlex
no