Encapsulation d’agents chimiothérapeutiques dans des nanoliposomes portés par des bactéries magnéto-aérotactiques
Bibliographic record
Abstract
La prolifération accrue de cellules tumorales exige une forte consommation d’oxygène appauvrissant le centre des tumeurs qui contient moins de 0,7 % d’oxygène et devient ainsi hypoxique. En dépit d’améliorations significatives, telles la pégylation des nanovecteurs qui permet une meilleure rétention dans la circulation sanguine et un meilleur ciblage tumoral, les plus récents nanovecteurs pharmaceutiques, comme les liposomes, les micelles et les nanoparticules polymériques ne parviennent cependant pas à rejoindre ces régions hypoxiques. Ainsi, même si 5 % de la dose administrée de nanovecteurs pégylés sont encore présents dans la circulation sanguine douze heures après son administration, seuls environ 2 % de ce médicament atteindront la tumeur.[...]
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".