Human Osteoblast-like Cells Are Permissive for Zika Virus Replication
Bibliographic record
Abstract
We read with great interest the letter by Roimicher, et al 1. The authors reported a case of a woman with a 4-year diagnosis of rheumatoid arthritis who achieved therapy-induced clinical remission 4 months before acquiring Zika virus (ZIKV) infection. The woman presented with fever, maculopapular rush, conjunctivitis, and arthralgia, and was tested for Chikungunya virus and ZIKV infection. The ZIKV genome was detected in blood and knee synovial fluid (SF). ZIKV viremia become negative after the end of clinical signs (Day 7); however, the patient experienced articular pain about 1 week later, and tested positive for ZIKV RNA in SF, while ZIKV viremia remained negative. These findings characterized for the first time a ZIKV infection localized within the joint of a patient, and raised a more general … Address correspondence to Dr. C. Caglioti, National Institute for Infectious Diseases L. Spallanzani, IRCCS, Laboratory of Virology, Via Portuense 292, Rome, Italy. E-mail: claudia.caglioti{at}inmi.it
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.010 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.013 | 0.011 |
| Insufficient payload (model declined to judge) | 0.002 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".