All-trans Retinoic Acid-induced Pseudotumor Cerebri during Treatment of Acute Promyelocytic Leukemia: A Case Report
Bibliographic record
Abstract
All-trans retinoic acid (ATRA), is a first line treatment of acute promyelocytic leukemia (APML). It is a derivative of vitamin A, and a relatively safe drug, but use of ATRA can lead to side effects including some life-threatening conditions such as differentiation syndrome and pseudotumor cerebri (PC). PC is a rare disorder characterized by headache, papilledema, and/or vision loss despite normal composition of cerebrospinal fluid and normal radiological imaging of brain. It may arise as a complication of ATRA during treatment of APML. ATRA induced PC occurs predominantly in the pediatric age group. We report a rare case of ATRA-induced PC in an adult, 25 year old female undergoing consolidation treatment for APML. On discontinuation of ATRA and treatment with acetazolamide and corticosteroids symptoms improved within 5 days. ATRA was reinstituted within 2 weeks at reduced dose with prophylactic acetazolamide. Later ATRA was tolerated well by the patient and consolidation therapy was completed.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".