Bibliographic record
Abstract
In this study, we have examined the metabolism of vitamin A (retinol) in adriamycin-induced cardiomyopathy in the rat model. Adriamycin was administered in 6 equal i.p. injections over a period of two weeks (cumulative dose 15 mg/kg). Three weeks after the treatment, retinol and 3H-radio labeled retinol were measured in heart, liver, kidney and plasma using HPLC method. In the storage organs, the liver and kidneys, stored amounts of vitamin A were assessed by measuring the levels of retinol palmitate. Activities of retinol mobilizing enzymes, bile salt-dependent retinol ester hydrolase (BSD-REH) and bile salt-independent retinol ester hydrolase (BSI-REH) were also examined in the liver. Levels of _-tocopherol, another known endogenous nonenzymatic antioxidant, were also examined using HPLC method. All of the results were compared with the matching controls. This study shows that retinol levels were strictly maintained in the heart and plasma, even in the severe failure stage. This may be due to the increased mobilization from the storage sites in the liver. Increased consumption in the heart was indicated by an increase in the radio-labeled retinol in this organ as well as in the plasma. The study shows that under condition the radio-labeled retinol in this organ as well as in the plasma. The study shows that under condition of increased myocardial oxidative stress, there is an increased consumption of antioxidant vitamin A. (Abstract shortened by UMI.)
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".