MétaCan
Menu
Back to cohort
Record W2792845223 · doi:10.1093/cercor/bhx313

Walking, Gross Motor Development, and Brain Functional Connectivity in Infants and Toddlers

2017· article· en· W2792845223 on OpenAlex
Natasha Marrus, Adam T. Eggebrecht, Alexandre A. Todorov, Jed T. Elison, Jason J. Wolff, Lyndsey Cole, Wei Gao, Juhi Pandey, Mark D. Shen, Meghan R. Swanson, Robert W. Emerson, Cheryl L. Klohr, Chloe M Adams, Annette Estes, Lonnie Zwaigenbaum, Kelly N. Botteron, Robert C. McKinstry, John N. Constantino, Alan C. Evans, Heather C. Hazlett, Stephen R. Dager, Sarah Paterson, Robert T. Schultz, Martin Styner, Guido Gerig, Bradley L. Schlaggar, Joseph Piven, John R. Pruett

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueCerebral Cortex · 2017
Typearticle
Languageen
FieldMedicine
TopicInfant Development and Preterm Care
Canadian institutionsMontreal Neurological Institute and HospitalMcGill UniversityHealth Sciences CentreUniversity of Alberta
FundersIntellectual and Developmental Disabilities Research Center, Washington University School of Medicine in St. LouisNational Institute of Child Health and Human DevelopmentNational Institute of Environmental Health SciencesNational Institute of Mental HealthNational Institutes of HealthSimons FoundationMcDonnell Center for Systems NeuroscienceIntellectual and Developmental Disabilities Research CenterEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentAutism Speaks
KeywordsGross motor skillNeuroscienceFunctional connectivityMotor areaBrain developmentMotor skillPhysical medicine and rehabilitationPsychologyMedicine

Abstract

fetched live from OpenAlex

Infant gross motor development is vital to adaptive function and predictive of both cognitive outcomes and neurodevelopmental disorders. However, little is known about neural systems underlying the emergence of walking and general gross motor abilities. Using resting state fcMRI, we identified functional brain networks associated with walking and gross motor scores in a mixed cross-sectional and longitudinal cohort of infants at high and low risk for autism spectrum disorder, who represent a dimensionally distributed range of motor function. At age 12 months, functional connectivity of motor and default mode networks was correlated with walking, whereas dorsal attention and posterior cingulo-opercular networks were implicated at age 24 months. Analyses of general gross motor function also revealed involvement of motor and default mode networks at 12 and 24 months, with dorsal attention, cingulo-opercular, frontoparietal, and subcortical networks additionally implicated at 24 months. These findings suggest that changes in network-level brain-behavior relationships underlie the emergence and consolidation of walking and gross motor abilities in the toddler period. This initial description of network substrates of early gross motor development may inform hypotheses regarding neural systems contributing to typical and atypical motor outcomes, as well as neurodevelopmental disorders associated with motor dysfunction.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.027
Threshold uncertainty score0.571

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.025
GPT teacher head0.269
Teacher spread0.243 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it