A229 CLINICAL AND ENDOSCOPIC CHARACTERISTICS OF LYMPHOCYTIC ESOPHAGITIS
Bibliographic record
Abstract
Lymphocytic esophagitis (LE) is a pathologic diagnosis characterized by intraepithelial lymphocytic (IEL) infiltration of the esophageal epithelium. It is a recently acknowledged disease entity, and remains underexplored in the literature. Moreover, the pathophysiology, clinical presentation and endoscopic associations of LE are still unclear. To characterize the demographic, clinical, pathologic and endoscopic findings of LE. This is a case series conducted at a single academic centre. Patients with histologic findings suggestive of LE from esophageal biopsies done from 2010 to 2016 were identified from a clinical database. Patient demographics, comorbidities, clinical presentations, treatments, imaging findings and endoscopic features were extracted from electronic medical records and descriptive statistics were performed. Twenty-four patients with LE were identified. The average age was 58.5 and 71% were male. Common comorbidities included HIV (20.8%), asthma (16.7%), and diabetes mellitus (12.5%). The most prevalent clinical presentations were dysphagia (75%), reflux (66.7%), and food bolus obstruction (16.7%). Endoscopy and imaging most frequently demonstrated esophageal rings or webs (50%), esophagitis (20.8%), strictures (20.8%), and furrows (16.7%). In 20.8% of patients, the treating gastroenterologist did not make a definitive clinical diagnosis. Treatments employed included proton pump inhibitors (62.5%), esophageal dilatation (37.5%) and topical steroids (16.7%). LE occurs predominately in males and a sizeable proportion demonstrate HIV positivity, dysphagia or reflux; frequent endoscopic abnormalities include esophageal rings, webs, and strictures. Treatment approaches were variable, although the most common modalities used were proton pump inhibitors, endoscopic dilatation and topical steroids. Further studies are needed to confirm these findings as well as characterize the natural history and efficacy of treatment modalities for this rare condition. None
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".