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Record W2792969515 · doi:10.15585/mmwr.mm6704a5

Outbreak of Seoul Virus Among Rats and Rat Owners — United States and Canada, 2017

2018· article· en· W2792969515 on OpenAlexaboutno aff
Janna L. Kerins, Sarah E Koske, James J. Kazmierczak, Connie Austin, Karen Gowdy, Antonia Dibernardo, J. D. Achenbach, Jill Baber, Gary Balsamo, Casey Barton Behravesh, David Blythe, Iwona Boraks-Pielechaty, Shelley Brown, Jennifer L. Brown, Robert M. Brucker, Barbara A. Bruen, Colin Campbell, Deborah Cannon, Beth Carlson, Kris Carter, Cynthia Cary, Caroline Castillo, Cheng‐Feng Chiang, Mary J. Choi, Ellen Christel, A. J. Clayton, Leah Colton, Laura Cronquist, David Damsker, William G. Davis, Annabelle de St. Maurice, Jordan L Dieckman, John R. Dunn, Drew D. Dycus, Elizabeth Ervin, Michelle Feist, Amanda Feldpausch, Mary Margaret Fill, Julie Gabel, Ann Garvey, Sarah C. Genzer, Suzanne Gibbons-Burgener, James Graziano, Victoria Hall, Russel Heisey, Heather Henderson, Janemarie Hennebelle, Leslie Hiber, Stacy Holzbauer, Jennifer House, Eddie Jackson, M. Harley Jenks, Dee Jones CDC, Susan Keller, John D. Klena, Rachel Klos, Barbara Knust, Anna Kocharian, Katrin Kohl, Gregory Langham, George D. Lathrop, Jennifer E. Layden, Kathryn Lehatto, Jodi Lovejoy, Kenneth Lowery, Nicole Lukovsky-Akhsanov, Nhiem Luong, Michael Maglio, Craig Manning, Chandra Marriott, Natalie S. Marzec, Michel Masters, Susan McClanahan, Lisa McCloskey, Shannon McKnight, Jennifer H. McQuiston, Sara McReynolds, Gianna Megaro, Maria Morales-Betoulle, Allyn K. Nakashima, Stuart T. Nichol, Julie Paoline, Nishi Patel, Ketan Patel, Dallin Peterson, Leah Posivak-Khouly, Nathaniel Powell, Howard Pue, Lawrence J. Purpura, Rachel Radcliffe, Nicole Reynolds, Linda Roesch, Pierre E. Rollin, Andrea L. Sandberg, Joni Scheftel, Betsy Schroeder, Irshad Ali Shaikh, Trevor Shoemaker, Jennifer L. Sidge, Tom Sidwa, Kim Signs, Amber Singh, Aaron Smee, Danielle Stanek, Mary Grace Stobierski, Anne Straily, Ute Ströher, Cassandra Tansey, Leslie Tengelsen, Beth Thompson, Susan L. Ward, Kimberly Warren, Susan P. Weinstein, Deborah Jones Weiss, André Weltman, Tigist Yirko, Joyce Zuzack, Peter Buck, Allen Grolla, Chris Huynh, L. Robbin Lindsay, Courtney Loomer, David Safronetz, Angela Sloan, Jim Strong, Joanne Tataryn, Linda Vrbova

Bibliographic record

VenueMMWR Morbidity and Mortality Weekly Report · 2018
Typearticle
Languageen
FieldMedicine
TopicViral Infections and Vectors
Canadian institutionsnot available
FundersNorth Dakota Department of AgricultureGeorgia Department of AgricultureTexas Department of State Health ServicesLouisiana Department of HealthMichigan Department of Health and Human ServicesIowa Department of Public HealthMinneapolis Medical Research FoundationCenters for Disease Control and PreventionGeorgia Department of Public HealthMaryland Department of Health and Mental HygieneIndiana State Department of HealthOhio Department of HealthUtah Department of HealthState of New Jersey Department of HealthMcKnight FoundationMinnesota Department of HealthPennsylvania Department of HealthNew York City Department of Health and Mental HygieneU.S. Department of StateColorado Department of Public Health and EnvironmentU.S. Department of Health and Human Services
KeywordsMedicineOutbreakTransmission (telecommunications)VirusRodentLeukopeniaHantavirusVirologyVeterinary medicineEnvironmental healthInternal medicine

Abstract

fetched live from OpenAlex

In December 2016, the Wisconsin Department of Health Services (WDHS) notified CDC of a patient hospitalized with fever, leukopenia, elevated transaminases, and proteinuria. The patient owned and operated an in-home rattery, or rat-breeding facility, with approximately 100 Norway rats, primarily bred as pets. A family member developed similar symptoms 4 weeks later, but was not hospitalized. Because both patients were known to have rodent contact, they were tested for hantavirus infections. In January 2017, CDC confirmed recent, acute Seoul virus infection in both patients. An investigation was conducted to identify additional human and rat infections and prevent further transmission. Ultimately, the investigation identified 31 facilities in 11 states with human and/or rat Seoul virus infections; six facilities also reported exchanging rats with Canadian ratteries. Testing of serum samples from 183 persons in the United States and Canada identified 24 (13.1%) with Seoul virus antibodies; three (12.5%) were hospitalized and no deaths occurred. This investigation, including cases described in a previously published report from Tennessee (1), identified the first known transmission of Seoul virus from pet rats to humans in the United States and Canada. Pet rat owners should practice safe rodent handling to prevent Seoul virus infection (2).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.022
Threshold uncertainty score0.163

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.002
Science and technology studies0.0050.001
Scholarly communication0.0010.000
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.036
GPT teacher head0.303
Teacher spread0.267 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations41
Published2018
Admission routes1
Has abstractyes

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