A139 ASYMPTOMATIC IBD IS A COMMON FINDING IN FIT POSITIVE INDIVIDUALS
Bibliographic record
Abstract
Inflammatory Bowel Disease is often present for months and even years before a formal diagnosis is made. This time represents a missed opportunity for early intervention that may have a significant impact on disease course and prevent unnecessary surgeries. The purpose of this study was to assess findings of undiagnosed IBD within Newfoundland and Labrador from the provincial colon cancer screening program. Data for this study was obtained in a prospective fashion using the Newfoundland and Labrador Colon Cancer Screening Program. Those enrolled in the study were between the ages of 50–74 at average risk for colon cancer. Between July 1, 2012 and June 30, 2016, participants were provided with two FIT tests – if a minimum of one test was ≥100ng/mL, participants were further evaluated via colonoscopy. Data on the patient’s age, gender, FIT value, presence of adenoma, pathology, and other variables were collected. Of the 21,371 FIT kits mailed out, 16,152 (75.6%) were returned, of which, 2694 (16.7%) had at least one FIT value ≥100ng/mL. At the time of analysis, 1831 participants had been further evaluated by colonoscopy. Colonoscopy identified 35 patients (1.9%) with undiagnosed inflammatory bowel disease, confirmed by pathology. Of those found to have IBD, 57.1% were female, 42.9% were male, and 54.3% had two positive FIT values. The age of those with IBD ranged from 50–71 with a mean of 59.5. The highest FIT value of those with IBD ranged from 100.0 to 18877.0 with a mean of 2048.1, 25th percentile of 180, 50th percentile of 518, and 75th percentile of 1463. For comparison, the mean highest FIT value for those with colon cancer was 4219.8, for those with an adenoma was 1140.2 and for those with no finding was 580.4. This study shows that undiagnosed inflammatory bowel disease in the fifth to seventh decade of life is not an uncommon occurrence. The prevalence of diagnosed IBD in Canada is estimated to be 0.428%, with 0.194% having ulcerative colitis and 0.234% having Crohn’s disease. Of the 16,152 participants who returned their FIT test, 0.27% were found to have undiagnosed IBD. These findings suggest that there is a substantial burden of undiagnosed IBD in Newfoundland and Labrador. None
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".