Abstract 15668: Diffuse Interstitial Myocardial Fibrosis is Associated With Abnormal Left Atrial Mechanics in Hypertension
Bibliographic record
Abstract
Background: Varying degrees of myocardial fibrosis may accompany LV remodeling associated with pressure overload. However, the correlates of diffuse myocardial fibrosis are poorly understood. Given the role of ECV on left ventricular diastolic compliance, we hypothesized that ECV is associated with abnormal atrial mechanics in hypertension. Methods: We studied 151 subjects with hypertension. ECV was measured with myocardial T1 mapping before and after the administration of gadolinium, in a mid-ventricular short axis plane. Longitudinal atrial mechanics were measured with SSFP MRI, from the 4-chamber and 2-chamber views, using tissue tracking (CVI42; Circle CV Imaging; Calgary, Canada). Results: In models that adjusted for demographics, body size, blood pressure, the presence of heart failure, diabetes and medication use, ECV was independently predictive of a poorer reservoir, conduit and booster pump function (Table). Conclusions: ECV is independently associated atrial dysfunction in hypertension. Diffuse myocardial fibrosis play a role in the development of atrial arrhythmias and/or HFpEF in hypertensive subjects.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".