Leukostasis-Related Fatal Cardiopulmonary Arrest as Initial Chronic Myeloid Leukemia Presentation
Bibliographic record
Abstract
Chronic myeloid leukemia (CML) is a BCR-ABL1-positive myeloproliferative neoplasm (MPN), which is usually diagnosed in chronic phase (CP-CML) and is considered curable in the era of tyrosine kinase inhibitors (TKIs). Leukostasis is an urgent complication more often of acute and less often of chronic leukemias. Regarding CML, leukostatic symptoms are uncommon in CP and in newly diagnosed patients, while being more often in advanced disease stages (accelerated or blastic phase). Leukostasis in CML is mostly presented with neurologic or respiratory symptoms. We present here a case of newly diagnosed CML in CP, which initially presented with leukostasis-related fatal cardiopulmonary arrest in a 59-year-old woman. J Med Cases. 2018;9(3):77-82 doi: https://doi.org/10.14740/jmc2993w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".