Cortical thickness in right frontal and left lingual gyri differentially mediate episodic memory for spatial contextual details across the adult lifespan
Bibliographic record
Abstract
Abstract Healthy aging is associated with declines in episodic memory and with widespread cortical thinning. These parallel declines suggest that age-related changes in cortical thickness may contribute to episodic memory decline with age. The current study uses a cross-sectional study design to examine whether regional cortical thickness mediates the relationship between age and episodic memory, as measured by a context memory task for faces. Mediation and conditional mediation models were tested using bootstrapping in order to determine how age-associated changes in regional cortical thickness mediated age-associated changes in performance on the context memory task. We observed that right superior frontal cortical thickness conditionally mediated spatial context memory only in middle-aged and older adults; and right caudal middle frontal cortical thickness conditionally mediated context memory only in older adults. Left lingual cortical thickness mediated spatial context memory across the adult lifespan, but this effect was most evident at midlife. Right parahippocampal cortical thickness mediated context memory, independent of age. We conclude that our cortical thickness results were generally consistent with the posterior-to-anterior shift in aging hypothesis (Davis et al., 2008) for episodic memory.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".