Nonlinear calcium ion waves along actin filaments control active hair–bundle motility
Why this work is in the frame
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Bibliographic record
Abstract
Abstract Actin filaments are highly dynamic semiflexible cellular biopolymers with diverse functions, such as cell motility. They also play the role of conduits for propagation of calcium ion waves. In this paper, we propose a new biophysical model that describes how actin filaments with their polyelectrolyte properties serve as pathways for calcium ion flows in hair cells. We show this can be utilized for the tuning of force–generating myosin motors. In this model, we unify the calcium nonlinear dynamics involved in the control of the myosin adaptation motors with mechanical displacements of hair– bundles. The model shows that the characteristic time scales fit reasonably well with the available experimental data for spontaneous oscillations in the inner ear. This model offers promises to fill a gap in our understanding of the role of calcium ion nonlinear dynamics in the regulation of processes in the auditory cells of the inner ear.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it