Long-term observation of ocular toxoplasmosis in immunocompetent children
Bibliographic record
Abstract
Introduction Toxoplasma gondii infection may result in retinochoroiditis and vision impairment. Aim of the study We conducted a long-term observation of symptoms and titres of serum anti-Toxoplasma IgG in children and adolescents. Thirty-four children (23 girls and 11 boys), aged one week to 18 years (mean 7.3 ±5.5 years) were observed for 2 to 17 years (mean 5.1 ±3.4 years). Diagnosis was based on detection of characteristic lesions in fundoscopy and positive serum anti-Toxoplasma IgG titres, and inflammation was confirmed by the leakage of dye in fluorescein angiography. Results In seven children the lesions were present at birth; they were bilateral and larger than 1 DD, in six of them they were accompanied by central nervous system abnormalities, and two children presented strabismus. Central localisation of toxoplasmosis, causing vision impairment, and inflammation recurrence, were found with similar frequency in these seven as in the other 27 children. Serum anti-T. gondii IgG ranged from 13 U/l to 1170 U/l, and titres were significantly higher in acute inflammation than in remission: 178 U/l vs. 90 U/l, p = 0.0016. Recurrences (one to three episodes) were noticed in 22/34 children: in all seven and in 15 out of 27 other children. Conclusions Ocular lesions in toxoplasmosis that initiated in foetal life were diffuse and led to progressive impairment of vision in childhood. Recurrence may be expected in more than half of all ocular toxoplasmosis cases despite antiparasitic treatment. Increase of serum anti-Toxoplasma IgG titre may indicate recurrence of retinochoroiditis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".