Bibliographic record
Abstract
Vitamin B6 (B6) plays an essential role in the metabolism of amino acids, synthesis of neurotransmitters, and regulation of energy homeostasis. B6 deficiency, plasma pyridoxal 5’-phosphate (PLP) concentration <20 nmol/L, has been associated with impaired immune responses and depression. Suboptimal B6 status, plasma PLP concentration between 20−30 nmol/L, has been associated with cardiovascular disease and cancer. A 19.4% prevalence of inadequate dietary B6 intake was reported among women aged 51−70 years and 9.6% women aged 19−30 years in the Canadian Community Health Survey 2004. However, there are very few data on biochemical B6 status among Canadian women. This thesis aimed to assess B6 status and to identify predictors of B6 status, in young and older adult women in Metro Vancouver, Canada. Vitamin B6 status in young adult women was assessed from an existing, descriptive, cross-sectional study with a convenience sample of 202 women aged 19−35 years in Metro Vancouver. Another descriptive, cross-sectional study was conducted in 223 older adult women aged 51−70 years in Metro Vancouver recruited by convenience sampling. B6 status was determined by fasting plasma PLP concentrations. Information on demographic and lifestyle characteristics and dietary intake was collected through questionnaires. The prevalence of B6 deficiency was 1.5% in young and 1.4% in older adult women. Suboptimal B6 status was 10.9% in young and 8.1% in older adult women. In both samples, the participants had high education levels and about 30% used B6-containing supplements. Body mass index, dietary B6 intake, and the use of supplemental B6 were significant predictors of plasma PLP concentrations in both samples. South Asian ethnicity was identified as a negative predictor of plasma PLP concentration in young adult women but a positive predictor in older adult women. Suboptimal B6 status was prevalent in convenience samples of young and older adult women in Metro Vancouver. Ethnicity, dietary B6 intake and the use of supplemental B6 should be considered as covariates for predicting B6 status in future studies. Considering the high socioeconomic status of the participants in this thesis, there is a need to investigate B6 status in a representative sample of Canadian women.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.002 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".