Identification of Novel Acetylation Sites in Nrf1 (NFE2L1) and Their Regulation by Sirtuin 1 (SIRT1)
Bibliographic record
Abstract
For cells to survive the damages of reactive oxygen species they must defend themselves. Cellular defense is accomplished by means of the antioxidant response element (ARE). One of the main factors involved in regulating the ARE is the nuclear factor (erythroid-derived 2)-like1 protein (Nrf1), this protein has not been thoroughly characterized, so the manner in which it is regulated is unknown. The deacetylase Sirtuin 1 (SIRT1) has been shown to regulate a relative of Nrf1, Nrf2. When SIRT1 was chemically inhibited, the acetylation of Nrf1 increased, indicating SIRT1 to be a regulator of Nrf1. When Nrf1 was deacetylated by SIRT1, a significant decrease in the activity of Nrf1 was observed. Under hypoxic conditions, it was observed that SIRT1 was a stronger regulator of Nrf1 activity than hypoxia. Two acetylation sites were identified in Nrf1; lysines 205 and 629. The deacetylation of Nrf1 resulted in a significant decrease in cellular senescence.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".