Biofilm Bakteri pada Penderita Rinosinusitis Kronis
Bibliographic record
Abstract
Banyak dilaporkan kegagalan pengobatan pada rinosinusitis kronis (RSK) disebabkan resistensi terhadap antibiotik. Beberapa penelitian menunjukkan bahwa biofilm bakteri berperan penting pada etiologi dan persistensi dari RSK. Penulisan tinjauan pustaka ini adalah untuk mengetahui implikasi biofilm bakteri pada penderita RSK. Rinosinusitis kronis adalah penyakit inflamasi mukosa hidung dan sinus paranasal yang berlangsung dalam waktu lebih dari 12 minggu. Biofilm adalah suatu struktur komunitas sel-sel bakteri yang ditutupi oleh matriks polimer yang dihasilkan sendiri dan menempel pada permukaan. Berbagai penelitian menunjukkan terdapatnya biofilm bakteri pada mukosa sinonasal penderita RSK dan berhubungan dengan resistensi terhadap pengobatan dengan antibiotika. Berbagai pemeriksaan untuk mendeteksi biofilm yaitu Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Confocal Scanning Laser Microscopy (CSLM), modifikasi Calgary Biofilm Device Assay, Tube Method dan Congo Red Agar Method. Beberapa terapi potensial untuk mengatasi biofilm pada RSK sedang berkembang.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.008 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".