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Record W2799888754 · doi:10.1161/circresaha.117.310909

Personal Omics for Precision Health

2018· review· en· W2799888754 on OpenAlexaff
Ryan Kellogg, Jessilyn Dunn, M Snyder

Bibliographic record

VenueCirculation Research · 2018
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicEpigenetics and DNA Methylation
Canadian institutionsKellogg's (Canada)
FundersNational Institute of Biomedical Imaging and BioengineeringNational Institute of Diabetes and Digestive and Kidney Diseases
KeywordsOmicsComputational biologyBiologyData scienceComputer scienceMedicineBioinformatics

Abstract

fetched live from OpenAlex

The convergence of scientific capability and technology that generates vast health data at diminishing cost has generated opportunities, challenges, and anticipation surrounding future data-centric healthcare models. Individualized health data spanning biomolecular, physiological, and environmental dimensions comprise a “personal omics profile”. Here we discuss methods and opportunities to bridge genome and dynamic physiology, detect disease at an early stage, and uncover lifestyle and environmental patterns associated with disease. Significant challenges exist to aggregate, integrate, and protect personal omics data to advance our understanding of disease, enable data-driven clinical decisions, and motivate individuals to sustain behavioral change.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.007
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.016
Threshold uncertainty score0.052

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0050.007
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0040.004
Science and technology studies0.0010.003
Scholarly communication0.0030.005
Open science0.0020.003
Research integrity0.0040.007
Insufficient payload (model declined to judge)0.0160.008

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.301
GPT teacher head0.528
Teacher spread0.227 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations69
Published2018
Admission routes1
Has abstractyes

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