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Mitochondrial cAMP-PKA signaling: What do we really know?

2018· review· en· 148 citations· W2800834898 on OpenAlex· 10.1016/j.bbabio.2018.04.005

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.
Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

Full frame distilled prediction

Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

Candidate categories
Meta-epidemiology (narrow), Research integrity
Consensus categories
Meta-epidemiology (narrow)
Domain
Candidate signal: noneConsensus signal: none
Study design
Candidate signal: Not applicableConsensus signal: none
Genre
Candidate signal: ReviewConsensus signal: Review
Teacher disagreement score
0.754
Threshold uncertainty score
1.000
Validation status
machine_predicted_unvalidated · codex-gemma-dda1882f352a

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0020.002
Meta-epidemiology (broad)0.0020.002
Bibliometrics0.0000.001
Science and technology studies0.0000.001
Scholarly communication0.0010.000
Open science0.0020.001
Research integrity0.0030.001
Insufficient payload (model declined to judge)0.0000.001

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.029
GPT teacher head0.301
Teacher spread
0.272 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Biochimica et Biophysica Acta (BBA) - Bioenergetics
Topic
Mitochondrial Function and Pathology
Field
Biochemistry, Genetics and Molecular Biology
Canadian institutions
Université de Moncton
Funders
Canadian Cancer SocietyFondation de la recherche en santé du Nouveau-BrunswickUniversité de MonctonAlzheimer SocietyNatural Sciences and Engineering Research Council of CanadaFondation Brain CanadaNew Brunswick Innovation FoundationHealth Research Foundation
Keywords
MitochondrionCytosolCell biologyOrganelleBiologyOxidative phosphorylationSignal transductionCell signalingRetrograde signalingReactive oxygen speciesHomeostasisBiochemistryEnzyme
Has abstract in OpenAlex
no