Associations between Plasma 25-Hydroxyvitamin D, Hormonal Contraceptives, and Premenstrual Symptoms
Bibliographic record
Abstract
Premenstrual symptoms are experienced by the majority of women and may cause significant personal and professional impairment; however, little is known about their pathophysiology and risk factors. The purpose of this thesis was to determine the prevalence of common premenstrual symptoms in a multiethnic Canadian population and to explore the associations of plasma 25-hydroxyvitamin D and hormonal contraceptive use with these symptoms. Symptom prevalence was found to vary widely between common symptoms, ranging from 11% to 75%. Prevalence of individual symptoms did not differ between ethnic groups, with the exception of cramps. Hormonal contraceptive use was associated with a reduction in the risk of experiencing several symptoms at moderate/severe severity. Plasma 25-hydroxyvitamin D was also inversely associated with the prevalence and severity of several premenstrual symptoms. These findings suggest HC use may be an effective targeted treatment and vitamin D status may be a risk factor for individual premenstrual symptoms.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".