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Anti-Inflammatory Effect of Nicavet-2500 in Rodent Models of Acute Inflammation

2018· article· en· W2800907110 on OpenAlex
David A. Areshidze, Lyudmila Timchenko, Igor Rzhepakovsky, Maria A. Kozlova, Iaroslavna A. Kusnetsova, Lyudmila A. Makartseva

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

venuePublished in a venue whose home country is Canada.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueJournal of Pharmacy and Nutrition Sciences · 2018
Typearticle
Languageen
FieldMedicine
TopicHuman Health and Disease
Canadian institutionsnot available
Fundersnot available
KeywordsInflammationOrganismSpleenImmune systemRodentBiologyModel organismImmunologyCell biologyBiochemistryEcologyGenetics

Abstract

fetched live from OpenAlex

This study examines the influence of the tissue preparation "NICAVET 2500" on an organism of mammals with use of rodent models of acute inflammation. It is established that action of a preparation leads to decrease in ESR. Hematologic and biochemical parameters also testify to anti-inflammatory action of "NICAVET 2500". Results of histological and morphometric research of a spleen and a thymus show processes of proliferation and migration of immunocytes, testifying to activization of immune reactions. In a thymus of rats of experimental group in comparison with control an increase in the dimensions of thymic lobules and also an increase in quantity of Hassal's bodies, testifying to intensification of synthesis of the thymic hormones participating in process of an immunopoesis are revealed. As a result of the use of the preparation an increase of ability of an organism to resist alteration and also essential decrease in a level of development of inflammatory reaction of an organism are observed. The conducted research demonstrates the expressed immunomodulatory action of a preparation "NICAVET 2500" at an experimental model of inflammation.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.343
Threshold uncertainty score0.166

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.041
GPT teacher head0.396
Teacher spread0.356 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it