393 Reproductive Parameters and Blood Metabolites in Young Female Rats Subjected to Feed Restriction and/or Ginger Administration.
Bibliographic record
Abstract
Forty-eight, 9-week old Sprague Dawley female rats (159 ± 13 g) were used to evaluate the effects of feed restriction and/or ginger oil (Zingiber officinale) supplementation on growth, reproductive parameters and blood metabolites. The experiment lasted for 40 days; 10 days of adaptation and intake assessment and 30 days of treatment and data collection. Animals were randomly divided into 4 treatment groups (12 rats/treatment) in a 2 x 2 factorial arrangement; ad libitum feed (CON), 25% feed restriction (G2), ad libitum feeding with 0.2 mL/rat ginger oil (G3), and 25% feed restriction plus 0.2 mL/rat ginger oil (G4). Animals in groups G2 and G4 received 75% of their pre-treatment feed intake (25% restriction). Rats were individually placed in plastic cages in a temperature-controlled room. Ginger oil was supplemented orally (gavage) while the non-ginger groups received water. Body weight (BW) and size were recorded weekly. Six rats from each group were sacrificed at the end of treatments for blood and tissue collection while the remaining rats were mated with mature males. Animals were fed ad libitum from mating onward. Data were analyzed by a two-way analysis of variance using SigmaPlot 11.0. Data for BW and size were analyzed by analysis of variance for repeated measures. No ginger by feed restriction interactions were detected in any of the tested parameters. Body size and BW increased as the experiment advanced (P<0.01), however, G2 had the lowest BW (P<0.05) towards the end of treatment. Cholesterol and triglycerides were unaffected by treatment while glucose and urea nitrogen were influenced by feed restriction (P<0.05); glucose was greater in feed-restricted animals while urea nitrogen was greater in animals on ad libitum feeding. Combined ovarian weights as well as reproductive tract weights were greater (P<0.05) in ginger-supplemented than non-supplemented animals. Similarly, rats on ad libitum feeding had greater ovarian weights (P<0.05) than those on restricted feeding. Birth date, litter size, litter weight, dam birth weight and pup weight were unaffected by treatment. In conclusion, ginger oil supplementation appears to have favorable effects on reproductive tract development and ovarian weights regardless of feed restriction.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".