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Record W2801264170 · doi:10.1111/anec.12552

Use of fragmented <scp>QRS</scp> in prognosticating clinical deterioration and mortality in pulmonary embolism: A meta‐analysis

2018· review· en· W2801264170 on OpenAlexaff
Amro Qaddoura, Geneviève C. Digby, Conrad Kabali, Piotr Kukla, Gary Tse, Benedict Glover, Adrián Baranchuk

Bibliographic record

VenueAnnals of Noninvasive Electrocardiology · 2018
Typereview
Languageen
FieldMedicine
TopicVenous Thromboembolism Diagnosis and Management
Canadian institutionsPublic Health OntarioUniversity of TorontoKingston General HospitalQueen's University
Fundersnot available
KeywordsMedicinePulmonary embolismMeta-analysisInternal medicineOdds ratioConfidence intervalMEDLINEQRS complexCardiogenic shockCardiologyEmergency medicineMyocardial infarction

Abstract

fetched live from OpenAlex

Background Fragmented QRS ( fQRS ) on electrocardiography is potentially valuable in prognosticating acute pulmonary embolism ( PE ). ECG is one of the first tests performed in the emergency department, quickly interpretable, noninvasive, inexpensive, and available in remote areas. We aimed to review fQRS 's role in PE prognostication. Methods We searched MEDLINE , EMBASE , Google Scholar, Web of Science, abstracts, conference proceedings, and reference lists until October 2017. Eligible studies used fQRS to prognosticate patients for the main outcomes of death and clinical deterioration or escalation of therapy. Two authors independently selected studies, with disagreement resolved by consensus. Ad hoc piloted forms were used to extract data and assess risk of bias. We used a random‐effects model to pool relevant data in meta‐analysis with odds ratios ( OR ) and 95% confidence intervals ( CI ), while all other data were synthesized qualitatively. Statistical heterogeneity was assessed using the I 2 index. Results We included five studies (1,165 patients). There was complete agreement in study selection. fQRS significantly predicted in‐hospital mortality ( OR [95% CI ], 2.92 [1.73–4.91]; p &lt; .001), cardiogenic shock ( OR [95% CI ], 4.71 [1.61–13.70]; p = .005), and total mortality at 2‐year follow‐up ( OR [95% CI ], 4.42 [2.57–7.60]; p &lt; .001). Adjusted analyses were generally consistent with these results. Conclusion Although few studies have explored the current study's question, they showed that fQRS is potentially valuable in PE prognostication. fQRS should be considered as an entry, along with other clinical and ECG findings, in a PE risk score.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: Meta-analysis
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.180
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0100.002
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.305
GPT teacher head0.447
Teacher spread0.143 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designMeta-analysis
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations10
Published2018
Admission routes1
Has abstractyes

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