Core Cross-linked Micelles Made of Glycopolymers Bearing Dopamine and Cholic Acid Pendants
Bibliographic record
Abstract
A series of block glycopolymers bearing galactose, dopamine, and cholic acid (CA) pendants have been synthesized by RAFT polymerization. These copolymers can self-assemble into micelles in water. The dopamine moieties, located near the interface of the core and shell of the micelles, can self-polymerize in a weakly basic solution, stabilizing the micelles in both water and organic solvent (DMSO). The cross-linked micelles are smaller in size than the uncross-linked precursors. Introducing more CA groups into the copolymers promotes the self-assembly to form larger aggregates, controls the cross-linking of the stabilized micelles, and facilitates the encapsulation of hydrophobic compounds such as Nile Red (NR). The amount of CA comonomers added also helps to control the cross-linking density, which affects the loading and release of NR. The core cross-linked micelles displayed a slow but sustained NR release and interact effectively with lectin (RCA 120 ), demonstrating their potential use as a biocompatible multifunctional platform for targeted release of drugs.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".