Core Cross-linked Micelles Made of Glycopolymers Bearing Dopamine and Cholic Acid Pendants
Bibliographic record
Abstract
A series of block glycopolymers bearing galactose, dopamine, and cholic acid (CA) pendants have been synthesized by RAFT polymerization. These copolymers can self-assemble into micelles in water. The dopamine moieties, located near the interface of the core and shell of the micelles, can self-polymerize in a weakly basic solution, stabilizing the micelles in both water and organic solvent (DMSO). The cross-linked micelles are smaller in size than the uncross-linked precursors. Introducing more CA groups into the copolymers promotes the self-assembly to form larger aggregates, controls the cross-linking of the stabilized micelles, and facilitates the encapsulation of hydrophobic compounds such as Nile Red (NR). The amount of CA comonomers added also helps to control the cross-linking density, which affects the loading and release of NR. The core cross-linked micelles displayed a slow but sustained NR release and interact effectively with lectin (RCA120), demonstrating their potential use as a biocompatible multifunctional platform for targeted release of drugs.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".