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The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity

2018· article· en· 721 citations· W2801885674 on OpenAlex· 10.1016/j.immuni.2018.04.016

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.
Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.033
GPT teacher head0.283
Teacher spread
0.250 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Immunity
Topic
Neuroinflammation and Neurodegeneration Mechanisms
Field
Neuroscience
Canadian institutions
McMaster University
Funders
Fondazione Umberto VeronesiMinistero della SaluteEidgenössische Technische Hochschule ZürichStiftung Synapsis - Alzheimer Forschung Schweiz AFSOntario Mental Health Foundation
Keywords
BiologyInnate immune systemTREM2NeuroscienceImmune systemMicrogliaSynapseReceptorImmune receptorImmunologyCell biologyVirologyMyeloid cellsGeneticsInflammation
Has abstract in OpenAlex
no