Metal Coordination to Unsymmetric 1,<i>n′</i>‐Disubstituted Ferrocene Histidine Peptides
Bibliographic record
Abstract
In this study, the coordination chemistry of unsymmetrical 1, n ′‐substituted ferrocene (Fc) peptide conjugates is explored, where the peptide substituents are two different histidine‐containing peptides. The resulting Fc‐conjugates serve as ligands for the formation of metal complexes, with the intention to generate complexes that possess a labile coordination site. The following Fc[CO‐His(Trt)‐OMe][COOMe] ( 1 ), Fc[CO‐His(Trt)‐Gly‐OMe][CO‐Gly‐OMe] ( 2 ), Fc[CO‐His(Trt)‐His(Trt)‐OMe][CO‐His(Trt)‐OMe] ( 3 ), and Fc[CO‐His(Trt)‐Gly‐His(Trt)‐OMe][CO‐Gly‐His(Trt)‐OMe] ( 4 ) were synthesized and characterized. Each compound forms discrete complexes with metal divalent metal ions Zn 2+ , Co 2+ and Cd 2+ , where a single metal ion is complexed by the metallo‐ligand, as was confirmed spectroscopically. The redox properties of the Fc group are influenced by metal coordination to the peptide substituents and anodic shifts occur upon the addition of metal ions. These follow the order Zn 2+ > Cd 2+ > Co 2+ . NMR experiments indicated imidazole rings are the site of metal coordination. Fc‐peptide conjugates display a switchable axial chirality that is dependent on metal complexation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".