Rare Combination of Adverse Effects Associated With Lamotrigine Treatment
Bibliographic record
Abstract
Lamotrigine (LTG) is an antiepileptic drug which is widely used in treatment of epilepsy. It is effective as an adjunctive treatment of refractory partial seizures and idiopathic generalized epilepsy in adults and children. However, patients are subject to some adverse effects with ongoing medication of LTG. Rare events associated with LTG medication such as hematological abnormalities and skin lesions have utmost clinical importance and often cause drug withdrawal. We present a case of a 23-year-old male who had leukopenia, thrombocytopenia and rash associated with LTG treatment. Clinician must be aware of serious side effects of LTG especially at the beginning of the treatment. Serious adverse effects such as leukopenia, thrombocytopenia and rash should be considered along with the other insignificant complaints such as nausea, dizziness and malaise. J Neurol Res. 2018;8(1-2):10-12 doi: https://doi.org/10.14740/jnr442w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.004 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".