Effect of garlic (Allium sativum) on lipid profiles, antioxidant activity and expression of scavenger receptor class B type I (SR-BI) in liver and intestine of hypercholesterolemic mice
Bibliographic record
Abstract
Garlic is one of the medicinal plants, which has shown many useful effects, including Antioxidant activity, hypolipidemic and hypocholesterolemic effects, anti-hypertensive and anti-diabetic effects. Scavenger receptor class B type I (SR-BI) is a cell-surface receptor which mediated selective cholesterol ester uptake from the HDL particle. SR-BI also has an important role in cholesterol absorption in the intestine. Animals were randomly divided into three groups (n=8); group 1: received chow + cholesterol (2%) + cholic acid (0.5%), group 2: chow + 4% (w/w) garlic extract + cholesterol (2%) + cholic acid (0.5%), and group 3: chow only. After one-month mice were sacrificed, blood was collected; lipid profile and blood glucose were determined enzymatically as well as mRNA and protein levels of SR-BI were determined by RT-PCR and westernblot respectively. Compared with hypercholesterolemic control, garlic extract significantly decreased total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides, Very Low-Density Lipoprotein-Cholesterol (VLDL-C) and atherogenic index (all of them P<0.05). The activity of Super oxide dismutase(SOD), glutathione (GSH) and catalase levels were markedly increased in garlic-treated animals compared with hypercholesterolemic animals (p<0.05). The plasma levels of MDA markedly reduced in garlic group compared with hypercholesterolemic group. Intestinal SR-BI mRNA and protein were significantly decreased in garlic extract mice treatment compared with hypercholesterolemic control. Levels of liver SR-BI protein significantly reduced in hypercholesterolemic group (P<0.05). In conclusion, garlic extract markedly reduced TC, LDL-C, TG, VLDL-C and atherogenic index, as compared with the hypercholesterolemic control group. On the other hand garlic extract led to down-regulation of SR-BI protein and mRNA in the intestine of mice.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".