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Record W2803894236 · doi:10.19070/2330-0027-130001e

Can plant-derived vaccines improve global human health?

2013· article· en· W2803894236 on OpenAlexaff
Hefferon KL

Bibliographic record

VenueInternational Journal of Virology Studies & Research · 2013
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicTransgenic Plants and Applications
Canadian institutionsUniversity of Toronto
Fundersnot available
KeywordsHuman healthGlobal healthVirologyBiologyEnvironmental healthMedicinePublic health

Abstract

fetched live from OpenAlex

Plants offer great advantages as production platforms for vaccines, antibodies and other biopharmaceutical proteins. Plantderived vaccines provide an alternative to conventionally- made vaccines by enabling delivery to be safe and effective through the oral consumption of edible plant tissue. Since a large number of infec-tious diseases enter the body through mucosal surfaces including the gut, vaccines which can be expressed within edible plant tissue present a select advantage. Not only do the plant tissues act as the delivery vehicle, they protect the antigen as it passes through the harsh environment of the gastrointestinal tract. Another advantage lies in the fact that, in contrast to bacterial expression systems, plants are capable of producing recombinant antigens that undergo post-translational modifications which resemble their mammalian-de-rived counterparts. Moreover, the cost of producing proteins from plants is only a fraction of the cost of proteins produced from comparable mammalian cell culture systems.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.801
Threshold uncertainty score0.299

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.064
GPT teacher head0.442
Teacher spread0.379 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2013
Admission routes1
Has abstractyes

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