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Record W2803894236 · doi:10.19070/2330-0027-130001e

Can plant-derived vaccines improve global human health?

2013· article· en· W2803894236 on OpenAlexaff
Hefferon KL

Bibliographic record

VenueInternational Journal of Virology Studies & Research · 2013
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicTransgenic Plants and Applications
Canadian institutionsUniversity of Toronto
Fundersnot available
KeywordsHuman healthGlobal healthVirologyBiologyEnvironmental healthMedicinePublic health

Abstract

fetched live from OpenAlex

Plants offer great advantages as production platforms for vaccines, antibodies and other biopharmaceutical proteins. Plantderived vaccines provide an alternative to conventionally- made vaccines by enabling delivery to be safe and effective through the oral consumption of edible plant tissue. Since a large number of infec-tious diseases enter the body through mucosal surfaces including the gut, vaccines which can be expressed within edible plant tissue present a select advantage. Not only do the plant tissues act as the delivery vehicle, they protect the antigen as it passes through the harsh environment of the gastrointestinal tract. Another advantage lies in the fact that, in contrast to bacterial expression systems, plants are capable of producing recombinant antigens that undergo post-translational modifications which resemble their mammalian-de-rived counterparts. Moreover, the cost of producing proteins from plants is only a fraction of the cost of proteins produced from comparable mammalian cell culture systems.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: none
Teacher disagreement score0.021
Threshold uncertainty score0.069

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.003
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.002
Scholarly communication0.0020.003
Open science0.0010.001
Research integrity0.0030.002
Insufficient payload (model declined to judge)0.0210.005

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.064
GPT teacher head0.442
Teacher spread0.379 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2013
Admission routes1
Has abstractyes

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