Abstract 13077: Maternal and Fetal Outcomes Among Pregnant Women With Frequent Premature Ventricular Complexes
Bibliographic record
Abstract
Introduction: Premature ventricular complexes (PVCs) in pregnancy are being increasingly recognized and many women have associated symptoms. Although thought to be benign, there is limited data on maternal and fetal outcomes in pregnancies with frequent PVCs. The objectives of this study were to describe the PVC burden and patterns, and to assess maternal and fetal outcomes in pregnancies with frequent PVCs. Methods: In this prospective observational cohort study, 40 consecutive pregnancies referred to our institution between January 2010 and March 2015 with PVC burden of greater than 0.1% on Holter studies were included. We reviewed electrocardiograms to identify PVC morphologies and Holter studies to determine PVC burden. PVC burden were stratified into low (n = 20) and high (n = 20) severity based on the median PVC burden of 6.8%. Student’s t-tests and Fisher’s exact test were used to evaluate difference in maternal and fetal outcomes by severity of PVC burden and beta-blocker (BB) use. Paired t-test was used to compare changes in PVC burden from antepartum to postpartum. Pearson analysis was performed to evaluate correlation between PVC burden and cardiac function. Results: Antepartum palpitations, pre-syncope, congestive heart failure, syncope, and deterioration in NYHA class were present in 70%, 25%, 5%, 2.5%, and 10% respectively. Fifty-five percent continued to have palpitation postpartum. Ninety-two percent of PVCs originated from right ventricular outflow tract. PVC burden decreased from 9.3 ± 9 % antepartum to 3.9 ± 5.4 % postpartum ( p = 0.118). There was no correlation between PVC burden and left ventricular end diastolic and end systolic dimensions, and left ventricular ejection fraction (r = 0.08, p = 0.74; r = 0.03, p = 0.92; r = -0.16, p = 0.50). Gestation at delivery was 39 ± 2 weeks with newborn weight of 3251 ± 576 grams. APGAR scores at 1 and 5 minutes were 8 ± 2 and 9 ± 1 respectively. One newborn had intrauterine growth restriction and 3 had meconium liquor. There was no difference in the above outcomes in subgroup analyses based on severity of PVC burden and BB use. Conclusions: Maternal and fetal outcomes in pregnancies with frequent PVCs were favorable. Severity of PVC burden and BB use did not have significant impact on maternal and fetal outcomes.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".