Curvature‐Induced Sorting of Lipids in Plasma Membrane Tethers
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Abstract Membrane curvature controls the spatial organization and activity of cells. Lipid sorting in cell membranes can be explained by matching lipid molecular shape to regions of different curvatures. A molecular view of curvature‐induced lipid sorting is obtained using coarse‐grained molecular dynamics. A model membrane consisting of an asymmetric bilayer of multiple lipid species is simulated. Curvature is induced by pulling a tether, that is, a bilayer nanotube, from a flat membrane. Pulling is performed both from the inner and outer leaflets, corresponding to directions in and out of the cell. Redistribution of different lipid types between the tether and the bilayer is observed, leading to spatial variations in the composition of both leaflets, and, in turn, softening of the tether. Depending on the direction of pulling, the lipid distributions and the tether properties differ. Formation of a tether from the planar membrane thus induces lipid sorting without phase separation.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it