EFFECT OF ANTIHYPERTENSIVE THERAPY ON PSYCHOLOGICAL AND COGNITIVE STATUS IN PATIENTS WITH ARTERIAL HYPERTENSION, OBESITY AND OBSTRUCTIVE SLEEP APNOEA
Bibliographic record
Abstract
Objective: To investigate the effect of antihypertensive therapy (AHT) on psychological and cognitive status of middle aged male patients with mild arterial hypertension (AH), obesity and obstructive sleep apnea (OSA). Design and method: We included 43 middle aged (42,8 [40,0; 45,6]) newly diagnosed male patients with AH, obesity (BMI 35,8 [34,2; 37,4] kg/m2) and severe OSA (AHI 52,4 [46,1; 58,6]/h). Patients didn’t have excessive daytime sleepiness (ESS 8,8 [7,6; 10,0]) and were otherwise healthy in terms of chronic conditions which may affect psychological and cognitive status. Patients underwent sleep study and ambulatory blood pressure (BP) monitoring. Our study consisted of 2 stages, initially all patients underwent AHT up-titration with a fixed dose combination of angiotensin-converting enzyme inhibitor and calcium antagonist (Perindopril arginine + Amlodipine), and diuretics (Indapamidi) if needed (visit 1- baseline, after 4–6 weeks when reaching target BP -visit 2), then patients were randomized to CPAP-therapy or continuation of solely AHT (visit 3). We present data solely on effect of AHT (visit 1 and visit 2). On all visits patients completed a series of self-report questionnaires: Epworth Sleepiness Scale (ESS), Karolinska Sleepiness Scale (KSS); Taylor Manifest Anxiety Scale adapted by Nemchinov T.A. (TMAS); Spielberg's State-Trait Anxiety Inventory (STAI) (S-STAI, state anxiety, T-STAI, trait anxiety); Zung Self-rating Depression Scale (SDS), the Short Form Health Survey (SF-36), Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA) and Frontal Assessment Battery (FAB). Results: On visit 2 - 95% of patient achieved target BP and additional 13% of patients achieved “dipper” BP profile. We didn’t observe changes in daytime sleepiness and psychosomatic status. We showed significant improvement in physical and mental aspects of quality of life and improvement in cognitive function according to MoCA and FAB questionnaires.Conclusions: In middle-aged newly diagnosed patients with AH, obesity and severe OSA, but without excessive daytime sleepiness, administration of antihypertensive therapy with a fixed-dose combination even in a short period of time showed a significant improvement in quality of life and cognitive function even before adding of CPAP-therapy.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".