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Record W2807649219 · doi:10.1007/s12311-018-0952-3

Cerebellar Modules and Their Role as Operational Cerebellar Processing Units

2018· review· en· W2807649219 on OpenAlexafffund
Richard Apps, Richard Hawkes, Sho Aoki, Fredrik Bengtsson, Amanda M Brown, Gang Chen, Timothy J. Ebner, Philippe Isope, Henrik Jörntell, Elizabeth P. Lackey, Charlotte L. Lawrenson, Bridget M. Lumb, Martijn Schonewille, Roy V. Sillitoe, Ludovic Spaeth, Izumi Sugihara, Antoine M. Valera, Jan Voogd, Douglas R. Wylie, Tom J. H. Ruigrok

Bibliographic record

VenueThe Cerebellum · 2018
Typereview
Languageen
FieldNeuroscience
TopicVestibular and auditory disorders
Canadian institutionsHotchkiss Brain InstituteWomen and Children’s Health Research InstituteUniversity of AlbertaUniversity of Calgary
FundersEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institute of Neurological Disorders and StrokeJapan Society for the Promotion of ScienceBiotechnology and Biological Sciences Research CouncilNatural Sciences and Engineering Research Council of CanadaCanadian Institutes of Health ResearchDirectorate for Biological SciencesNational Institutes of HealthCentre National de la Recherche ScientifiqueUniversité de StrasbourgAgence Nationale de la RechercheNederlandse Organisatie voor Wetenschappelijk OnderzoekTexas Children's HospitalFondation pour la Recherche MédicaleIntellectual and Developmental Disabilities Research CenterMinisterie van Volksgezondheid, Welzijn en SportBaylor College of MedicineHamill FoundationErasmus Medisch Centrum
KeywordsCerebellumCompartmentalization (fire protection)Modular designNeuroscienceComputer scienceCognitive sciencePsychologyBiology

Abstract

fetched live from OpenAlex

The compartmentalization of the cerebellum into modules is often used to discuss its function. What, exactly, can be considered a module, how do they operate, can they be subdivided and do they act individually or in concert are only some of the key questions discussed in this consensus paper. Experts studying cerebellar compartmentalization give their insights on the structure and function of cerebellar modules, with the aim of providing an up-to-date review of the extensive literature on this subject. Starting with an historical perspective indicating that the basis of the modular organization is formed by matching olivocorticonuclear connectivity, this is followed by consideration of anatomical and chemical modular boundaries, revealing a relation between anatomical, chemical, and physiological borders. In addition, the question is asked what the smallest operational unit of the cerebellum might be. Furthermore, it has become clear that chemical diversity of Purkinje cells also results in diversity of information processing between cerebellar modules. An additional important consideration is the relation between modular compartmentalization and the organization of the mossy fiber system, resulting in the concept of modular plasticity. Finally, examination of cerebellar output patterns suggesting cooperation between modules and recent work on modular aspects of emotional behavior are discussed. Despite the general consensus that the cerebellum has a modular organization, many questions remain. The authors hope that this joint review will inspire future cerebellar research so that we are better able to understand how this brain structure makes its vital contribution to behavior in its most general form.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.003
Threshold uncertainty score0.008

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0030.002
Science and technology studies0.0000.002
Scholarly communication0.0010.002
Open science0.0010.001
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.050
GPT teacher head0.289
Teacher spread0.238 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations226
Published2018
Admission routes2
Has abstractyes

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Same venueThe CerebellumSame topicVestibular and auditory disordersFrench-language works237,207