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Multi-laboratory comparison of three commercially available Zika IgM enzyme-linked immunosorbent assays

2018· article· en· W2809752484 on OpenAlexaff
Alison Jane Basile, Christin H. Goodman, Kalanthe Horiuchi, Angela Sloan, Barbara W. Johnson, Olga Kosoy, Janeen Laven, Amanda J. Panella, Isabel Sheets, Freddy A. Medina, Emelissa J. Mendoza, Monica Epperson, Panagiotis Maniatis, Vera Semenova, Evelene Steward‐Clark, Emily Wong, Brad J. Biggerstaff, Robert S. Lanciotti, Michael Drebot, David Safronetz, Jarad Schiffer

Bibliographic record

VenueJournal of Virological Methods · 2018
Typearticle
Languageen
FieldMedicine
TopicMosquito-borne diseases and control
Canadian institutionsPublic Health Agency of Canada
FundersNational Institutes of Health
KeywordsConcordanceVirologyBiologyZika virusImmunoglobulin MMedicineImmunologyImmunoglobulin GAntibodyInternal medicineVirus

Abstract

fetched live from OpenAlex

• ZIKV IgM kits from InBios, NovaTec and Euroimmun were compared in 3 separate labs. • InBios kit was most sensitive; Novatec and Euroimmun kits were most specific. • Concordance across the labs was high for both the NovaTec and Euroimmun IgM + IgG kits. • The NS1-based NovaTec and Euroimmun kits may be useful in confirmation of infection for a portion of patients and to reduce the number of PRNT’s required.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.021
metaresearch head score (Gemma)0.026
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.021
Threshold uncertainty score0.108

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0210.026
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0030.002
Science and technology studies0.0010.001
Scholarly communication0.0020.001
Open science0.0010.001
Research integrity0.0020.001
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.115
GPT teacher head0.437
Teacher spread0.322 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations24
Published2018
Admission routes1
Has abstractyes

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